Noise spectra of stochastic pulse sequences: application to large scale magnetization flips in the finite size 2D Ising model

We provide a general scheme to predict and derive the contribution to the noise spectrum of a stochastic sequence of pulses from the distribution of pulse parameters. An example is the magnetization noise spectra of a 2D Ising system near its phase transition. At $T\le T_c$, the low frequency spectra is dominated by magnetization flips of nearly the entire system. We find that both the predicted and the analytically derived spectra fit those produced from simulations. Subtracting this contribution leaves the high frequency spectra which follow a power law set by the critical exponents.Comment: 4 pages, 5 figures. We improved text and included a predicted noise curve in Figure 4. 2 examples from Figure 3 are remove

Gene Co-expression Network and Copy Number Variation Analyses Identify Transcription Factors Associated With Multiple Myeloma Progression

Multiple myeloma (MM) has two clinical precursor stages of disease: monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). However, the mechanism of progression is not well understood. Because gene co-expression network analysis is a well-known method for discovering new gene functions and regulatory relationships, we utilized this framework to conduct differential co-expression analysis to identify interesting transcription factors (TFs) in two publicly available datasets. We then used copy number variation (CNV) data from a third public dataset to validate these TFs. First, we identified co-expressed gene modules in two publicly available datasets each containing three conditions: normal, MGUS, and SMM. These modules were assessed for condition-specific gene expression, and then enrichment analysis was conducted on condition-specific modules to identify their biological function and upstream TFs. TFs were assessed for differential gene expression between normal and MM precursors, then validated with CNV analysis to identify candidate genes. Functional enrichment analysis reaffirmed known functional categories in MM pathology, the main one relating to immune function. Enrichment analysis revealed a handful of differentially expressed TFs between normal and either MGUS or SMM in gene expression and/or CNV. Overall, we identified four genes of interest (MAX, TCF4, ZNF148, and ZNF281) that aid in our understanding of MM initiation and progression

On the exactness of soft theorems

Soft behaviours of S-matrix for massless theories reflect the underlying symmetry principle that enforces its masslessness. As an expansion in soft momenta, sub-leading soft theorems can arise either due to (I) unique structure of the fundamental vertex or (II) presence of enhanced broken-symmetries. While the former is expected to be modified by infrared or ultraviolet divergences, the latter should remain exact to all orders in perturbation theory. Using current algebra, we clarify such distinction for spontaneously broken (super) Poincar\'e and (super) conformal symmetry. We compute the UV divergences of DBI, conformal DBI, and A-V theory to verify the exactness of type (II) soft theorems, while type (I) are shown to be broken and the soft-modifying higher-dimensional operators are identified. As further evidence for the exactness of type (II) soft theorems, we consider the alpha' expansion of both super and bosonic open strings amplitudes, and verify the validity of the translation symmetry breaking soft-theorems up to O(alpha'^6). Thus the massless S-matrix of string theory "knows" about the presence of D-branes.Comment: 35 pages. Additional mathematica note book with the UV-divergenece of the 6-point amplitude in AV/KS theor